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ISCB2014_abstract_book

136 ISCB 2014 Vienna, Austria • Abstracts - Poster PresentationsWednesday, 27th August 2014 • 15:30-16:00 Monday25thAugustTuesday26thAugustThursday28thAugustAuthorIndexPostersWednesday27thAugustSunday24thAugust P4.5.12 Correlation between the degree of grade of astrocytomas and the current value of motor-evoked potential during brain surgery S Asano1 , T Nakagomi1 , K Furuya1 , A Morita2 , N Kawahara3 , T Toyoda4 , T Haisa5 , M Murakami6 , K Hoya6 , A Matsuno1 1 Dep. of Neurosurgery, Teikyo University School of Medicine, Tokyo, Japan, 2 Dep. of Neurosurgery, Nippon Medical School, Tokyo, Japan, 3 Dep. of Neurosurgery, Yokohama City Univ. Hospital, Yokohama, Japan, 4 Dep. of Neurosurgery, JCHO Tokyo-Shinjuku Med. Center, Tokyo, Japan, 5 Dep. of Neurosurgery, JR Tokyo General Hospital, Tokyo, Japan, 6 Dep. of Neurosurgery, Teikyo Univ. Chiba Med. Center, Ichihara, Japan Background: During brain tumor surgery, we have sometimes received unconfirmed grading of the astrocytomas in the intraoperative rapid his- tological diagnoses. However, we have had some correlation between the grading of the astrocytomas and the current value of the motor-evoked potential (MEP) monitoring. Methods: From 1995 to 2013, we performed MEP monitoring with anodal five-train stimulation of the brain surface of the primary motor cortex and the lead of contralateral muscle of the ball of the thumb during tumor removal. We retrospectively reviewed the final histological results and the current values of MEP, nitrous oxide, muscle relaxant. In all cases, we used intravenous anesthesia with porpofol. Results: Twenty-six cases were extracted. They were 15 females and 11 males, and mean age was 52±17 years. During their anesthesia, for 12 cas- es nitrous oxide was used, and for five cases muscle relaxant was admin- istered. Mean current value of the beginning MEP was 13.7±5.9 mA, and that of the last MEP was 17.4±7.1 mA. In their histological final diagnoses, the number of grade II astrocytomas was 10 (B-group), and that of grade III and IV astrocytomas were 4 and 12, respectively (total 16 cases: M-group). In the multivariate analysis with logistic regression analysis with step-wise method, we yielded two significant variables: age (odds ratio[B/M] 0.936, p=0.021) and current of the last MEP (odds ratio[B/M] 1.16, p=0.034). Conclusion: Our logistic results suggested that the current value of last MEP had negative correlation to the degree of malignancy of astrocyto- mas.   P4.5.61 Calculation of target range values on a continuous scale in immunosuppression following solid organ transplantation M Harden1 , T Friede1 1 Universitätsmedizin Göttingen, Göttingen, Germany Solid organ transplantation is followed by lifelong immunosuppression to avoid rejection of the donor‘s graft. Since most immunosuppressive drugs might harm the recipient‘s body in the long run, drug doses need to be monitored and changed over time. In practice, one tries to keep the drug concentrations within a target range to avoid both, rejection of the organ and harmful effects due to too large doses. Since existing target ranges are mainly based on expert opinions, we present different approaches to construct target ranges based on statistical models. We assume two binary endpoints with an event on one endpoint preclud- ing the observation of an event on the other endpoint, and model the risks of these events simultaneously, related to a continuous covariate (e.g. drug concentration). Based on these risk models, we calculate a lower and an upper cutoff value for the dose. We propose several methods to construct confidence intervals for both cutoff points, like inverse regression and normal approximations. Since repeated measurements play a major role in these kind of analyses, we discuss approaches to combine data/ account for time-varying effects. Performance of all methods will be compared based on simulated data, covering coverage probability and sample size. The investigations are mo- tivated by clinical trials in liver transplantation. P4.5.71 Population-based metabolic syndrome risk score and its determinants: the Isfahan Healthy Heart Program SM Hosseini1 1 Department of Biostatistics & Epidemiology, Isfahan, Islamic Republic of Iran Background: Metabolic Syndrome (MetSy), a most important predispos- ing factor for non-communicable diseases. Given different definitions used for the MetSy, recently using a score termed“Continuous MetSy Risk Score (CMetSyS)”is recommended. The Aim of this study was to provide a CMetSyS in a population-based sample of Iranian adults, and to assess its determinants. Methods: The data of the baseline survey of a community trial entitled “the Isfahan Health Heart Program“has been used. The MetSy was defined according to the Revised National Cholesterol Education Program Third Adult Treatment Panel. All probable predictive models and their predic- tive performance were provided using leave- one- out cross validated logistic regression and the Receiver Operation Characteristic curve meth- ods. Multiple Linear regression was performed to assess factors associated with the CMetSyS. Results: The study population consisted of 8313 persons. The MetSy was documented in 1539 persons (21.86%). Triglycerides and waist circumfer- ence were the best predictive components and fasting plasma glucose had lowest area under curve (AUC). The AUC for our best model was 95.36(94.83- 95.83%). The best predictive cut off for this risk score was -1.151 with 89% sensitivity and 87.93% specificity. Conclusion: We provided four population based leave- one- out cross validated risk score models, with moderate to perfect predictive perfor- mance to identify the MetSy in Iranian adults. The CMetSyS had significant associations with high sensitive C-reactive protein, body mass index, lei- sure time and work place physical activity as well as age and gender.   P4.5.72 Comparison of reference curves of anthropometric indices in two national studies conducted among Iranian children in 2003-2004 and 2009-2010 SM Hosseini1 1 Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran Objectives: This study aims to compare the curves of anthropometric measures obtained in two national studies conducted among Iranian chil- dren and adolescents in 2003-2004 and 2009-2010. Methods: Anthropometric measures obtained in two nationwide surveys conducted in 10-18-year-old Iranian students (n=15883 in 2003-2004 and n=5312 in 2009-2010)were compared.LMS Chart Maker Pro program was used to develop age- and gender- specific percentiles and to smooth and fit the model. Outlier data were detected with Z Scores graph and ex- cluded from the analysis. Normality of the data and goodness-of-fit were examined via Detrended Q-Q plot and Q-Tests, respectively. Then the per- centile curve graphs were plotted by using SAS software. Results: Body mass index was higher in girls than in boys in most percen- tiles, especially in the higher ones. Height curves did not show consider- able changes in two studies. Boys´ weight was lower than girls´ up to 15 years, and thereafter it became higher. In approximately all ages, boys´ waist circumference was higher in boys than in girls. Waist-to-height-ratio, especially in higher percentiles, was greater in boys than in girls approxi- mately up to 13 years. Conclusion: The growth charts of Iranian children and adolescents aged 10-18 years have changed over 5 years. Given the changes of reference curves of anthropometric measures over time, repeated surveys should be conducted to provide age- and gender-specific reference curves in dif- ferent ethnic groups.

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