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ISCB 2014 Vienna, Austria • Abstracts - Poster Presentations 133Wednesday, 27th August 2014 • 15:30-16:00 Monday25thAugustTuesday26thAugustThursday28thAugustAuthorIndexPostersWednesday27thAugustSunday24thAugust Methodology: A cross-sectional study was conducted among 412 stu- dents at different medical colleges in Karachi. For measuring internet addiction the Internet addiction test tool was ap- plied. This test was developed by Yung (1998). Yung defined 20-39 points as an average user, 40-69 points as a possible or intermittent user, and more than 70 points as an addicted user. The subjects’psychological well- being were assessed by self-reporting questionaire-20 (SRQ20). Results: Internet addiction test showed that 74% of the sample were aver- age internet users, 24% as problem over-users and 2% as addicted to the internet. The score of psychological morbidity was higher in internet ad- dicted or problem over-users as compare to average user (p value<0.001). over-users and addicts spending increasingly more time in online activi- ties, being more socially anxious, and gaining greater support from inter- net social networks (p value=0.003) and online chatting (p value=0.01) than average internet users. Conclusion: Internet addiction is prevalent among students and Key health messages and interventions to reduce stress and anxiety among students may help in curtailing the burden of this disease which has seri- ous adverse consequences.   P4.4.15 Quality of life (QoL) after stroke in five European populations assessed by health survey form (SF-12) and EuroQoL (EQ-5D) S Ayis1 , C Mckevitt1 , A Rudd2 , D Parkin1 , C Wolfe1 1 King’s College, London, United Kingdom, 2 St Thomas’ Hospital, London, United Kingdom   Background: Health-related quality of life (HRQoL) of stroke patients is likely to be impaired, due to functional and psycho-social limitations. Little is known about differences in HRQoL in different countries. The generic measure (SF-12) and a preference based measure (EQ-5D) were used to understand the distribution of HRQoL in five European countries. Methods: Data on 1,848 ischemic or intra-cerebral haemorrhage (ICH) stroke patients were obtained from population-based registers in five European countries: Dijon (France); Kaunas (Lithuania); London (UK); Warsaw (Poland), and Sesto-Fiorentino (Italy), between 2004 and 2006. Quality of life was measured using the physical component summary (PCS) and the mental component summary (MCS) of SF-12. EQ-5D scores were derived using a standardized response mapping algorithm, based that predicts probabilities of response for EQ-5D questions, using SF-12 responses. Mixed effect regression models were used to investigate varia- tions in HRQol, between populations, adjusting for case-mix, and socio- demographic factors. Results: The PCS and MCS scores differed significantly across countries. Lower HRQoL estimates were associated with old age, incontinence, and physical dependency in the acute phase. Dijon, has the lowest utility score with a difference of 0.11 (0.06-0.16) significantly lower than London (refer- ence) and Sesto-Fiorentino, and Warsaw both have a utility of 0.07 (0.2- 0.11) significantly higher than London. Conclusion: HRQoL of stroke patients varied widely across populations. There were significant associations between quality of life and patient characteristics. Extracting EQ-5D provides important information that may be used to estimate quality adjusted life years (QALY), to interpret QALY and compare costs across populations. P4.4.46 Discrepancies in exercise therapy prescriptions after hip replacement: a multicenter survey of surgeons, rehabilitation physicians and physiotherapists C Eulenburg1 , A-L Rahlf2 , A Kutasow2 , A Zech2 1 University Medical Center, Medical Biometry and Epidemiology, Hamburg, Germany, 2 Institute for Human Movement Science, Hamburg Univerity, Hamburg, Germany   Total hip replacement is one of the most performed surgeries across the world in the past decade. With ageing of the population, the number of patients requiring hip surgery may even increase. Rehabilitation after surgery is expected to reduce pain and optimize the functional recovery. By now, evidence-based therapy guidelines on rehabilitation after hip re- placement are not reported.The objective of our study was the evaluation of the present rehabilitation practice in Germany and the analysis of dis- crepancies among rehabilitation facilities. In a multicentre cross-sectional study, aims, interventions, exercise dos- age prescriptions and individual beliefs for postoperative treatment were assessed among rehabilitation professionals using a standardized questionnaire. Furthermore, we collected information on profession and experience of subjects and on the type of facility. Statistical analysis con- tained linear mixed models, accounting for random effects of the centres. To evaluate the accordance among subjects, an agreement measure was constructed. 313questionnairesfrom28rehabilitationcentreswereavailableforstatisti- cal analysis. Results show a high variability of the current practice. Subjects disagreed on more than half of the requested items. Recommendations concerning the time interval between surgery and start of rehabilitation differed significantly between professions. Findings reveal that the current rehabilitation practice after hip replace- ment in Germany is very inconsistent. The measured variability among professions suggests that the therapies may follow personal experiences and convictions more than standardized guidelines.   P4.4.94 Application of propensity-score matching: comparison of CT and ultrasonography in the effect on negative appendectomy J Lee1 , S Ahn1 , JH Park1 , HJ Kim2 , B Kim1 , SH Park2 , KH Lee1 1 Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea, 2 University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea   Purpose: The aim of this study was to compare computed tomography (CT) and ultrasonography (US) as the preoperative first-line imaging using propensity score matching, measured in terms of negative appendectomy rate (NAR) retrospectively. Materials and methods: From the original database which was con- ducted by the Low-dOse CT AppendicitisTrial (LOCAT) group, we included 2312 adolescents and adults patients who visited the site emergency de- partments and underwent appendectomy at 11 hospitals in metropolitan Seoul in 2011. We carefully selected 11 independent variables regard- ing patients and hospital characteristics and evaluated any imbalance between the CT and the US group. The propensity score was calculated using a logistic regression with the confounders and their pair-wise in- teraction terms. Matching was performed with greedy algorithm and 1:1 ratio. Finally, the effect of imaging modalities on NAR was assessed using McNemar’s test and conditional logistic regression analysis in the matched subgroups. Results: Before matching, NAR in the US group was significantly higher than in the CT groups (Chi-square test: χ2=7.429; P=.006; odds ratio [OR], 2.429; 95% confidence interval [CI]: 1.319, 4.473; P=.004). The results of propensity score matching revealed no significant differ-

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