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ISCB2014_abstract_book

ISCB 2014 Vienna, Austria • Abstracts - Poster Presentations 129Wednesday, 27th August 2014 • 15:30-16:00 Monday25thAugustTuesday26thAugustThursday28thAugustAuthorIndexPostersWednesday27thAugustSunday24thAugust analysis. Frequency and intensity of intervention strategies and outcome assessments were compared. The primary outcome was self-reported seven-day point prevalence (PP) at 4-weeks since the quit day. Secondary outcome was self-reported PP at 3 months. Treatment evaluations were performed on the principle of intention-to- treat. Participants who were lost to follow-up were treated as smokers. Generalized linear mixed models were fit to estimate the overall treatment effect, while accounting for clustering within individual studies. Estimates were adjusted for age, biological sex, socioeconomic status, previous quit attempts, and the baseline Fagerstrom score. There was no evidence of heterogeneity across individual studies. Overall, 28% of the smokers in the intervention group (1188/4202) quit smoking at 4-weeks, compared to 12% in the control (499/4113).The adjusted odds ratio (OR) was 2.9 (95% CI 2.58-3.28, p-value<.0001). A strong but reduced treatment effect was observed at 3-months (OR 1.88, 95% CI 1.53-2.32, p- value<.0001). Data from across four countries suggest that mobile phone-based smok- ing cessation programs have a consistent effect at increasing the chance of quitting across a diversity of cultures. P4.1.87 Diagnostic accuracy of Pap testing and human papillomavirus DNA testing in cervical cancer screening in Korea MJ Ko1 , Y Lee2 , J Shim1 , S Choi1 , J Kim1 1 National Evidence-based Healthcare Collaborating Agency, Seoul, Republic of Korea, 2 CHA Bundang Medical Center, Gyeonggi-do, Republic of Korea   Although screening program based on Pap testing (PAP) has substantially reduced cervical cancer in Korea, there is a paucity of study to compare the diagnostic accuracy among screening methods. This study performed a systematic review and meta-analysis of accuracy for PAP and Human papillomavirus DNA Testing (HPV) among asymptomatic women. Studies were included if PAP and/or HPV were conducted as index test among Koreans and published after 1995. We extracted sensitivity and specificity for the detection of cervical intraepithelial neoplasia 1(CIN 1) or worse based on colposcopy and histology of colposcopy-targeted biopsies. Two independent reviewers appraised and rated the quality of studies using the Quality Assessment of Diagnostic Accuracy (QUADAS- II). Summary ROC curve and bivariate random effects model were applied to synthesize diagnostic accuracy with 95% confidence interval. The rat- ings of risk of bias among 44 papers were as follows; most papers were categorized into unclear in the selection and application criteria. Bivariate random effects meta-analysis estimated the pooled sensitivity and speci- ficity of 21 studies for PAP as 0.85(95% CI: 0.77-0.90) and 0.74(95% CI: 0.58- 0.86), respectively for detecting ascus or worse. In HPV test, based on 24 studies, the pooled sensitivity and specificity was 0.76(95% CI: 0.68-0.82), and 0.80(95% CI: 0.73-0.86), respectively. PAP appeared to have a higher sensitivity but lower specificity than that of HPV. However, included studies had poor or unclear quality with respect to in- terpretation of the test results. More rigorous studies are needed.   P4.1.108 Mean platelet volume and coronary artery disease: a systematic review and meta-analysis N Sansanayudh1 , D Muntham2 , T Anothaisintawee3 , P Numthavaj3 , S Rattanasiri3 , MM Evoy4 , J Attia4 , A Thakkinstian3 1 Phramongkutklao Hospital, Bangkok, Thailand, 2 Mahidol University, Bangkok, Thailand, 3 Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 4 Faculty of Health and Medicine, University of New Castle, Callaghan, Australia   Background: Platelets play an important role in the pathophysiology of coronary artery disease (CAD). Mean platelet volume (MPV) has been pro- posed as platelet reactivity, and might emerge as a potential marker of CAD risk. Objective: To conduct a meta-analysis aiming at comparing mean differ- ence in MPV between CAD and controls, and pooling the odds ratio (OR) of CAD in those with high versus low MPV. Methods: We searched MEDLINE since initiations to 12 March 2013. All observational studies that reported MPV in CAD and control groups were included. Two reviewers independently extracted data. An unstan- dardised mean difference (USMD) with a random-effects model was ap- plied for pooling the mean difference, and DerSimonian & Laird method was used for pooling ORs. Results: Of the 1092 identified studies, 40 were included in this meta- analysis. The MPV was significantly larger in patient with CAD than con- trols with the USMD of 0.70 fL (95% CI: 0.55, 0.85). The USMD of MPV in acute coronary event and stable CAD were 0.84 fL (95% CI: 0.63, 1.04) and 0.55 fL (95% CI: 0.32, 0.78), respectively. Patients with higher MPV (≥ 7.3 fL) also had higher odds of having CAD than patients with lower MPV with a pooled OR of 2.28 (95% CI: 1.46, 3.58). Conclusion: Larger MPV was associated with CAD. Patients with MPV ≥ 7.3 fL was higher odds of having CAD. These findings suggest that MPV may be an useful marker in patients with coronary artery disease. P4.1.131 The association between the IRF6 genes and non-syndromic cleft lip with or without cleft palate: Systematic review and meta-analysis S Rattanasiri1 , K Wattanawong1 , A Thakkinstian1 1 Ramathibodi Hospital, Mahidol University, Bangkok, Thailand   Objective: A systematic review and meta-analysis was performed aiming at determining association between IRF6 genes and non-syndromic cleft lip with or without cleft palate (NSCLP). Methods: Studies published from 2004-2013 were retrieved for 3 poly- morphisms: rs2235371 (n=13), rs2013162 (n=7) and rs642961 (n=8). Data were independently extracted by two reviewers. Minor allele frequencies (MAF) in control groups were pooled. Odds ratio (OR) of genotypic effects were estimated using a mixed-effect logit regression. Results: For rs2235371 polymorphism, the pooled MAFs in 7 and 5 Asian- and Caucasian-studies were 0.36 (95%CI: 0.28, 0.43) and 0.08 (95% CI: 0.05, 0.12), respectively. The pooled OR1 (AA vs GG) and OR2 (GA vs GG) were respectively 0.49 (95% CI: 0.37, 0.63) and 0.60 (95% CI:0.51,0.71) in Asians, and 0.38 (95% CI: 0.18, 0.80) and 0.67 (95% CI: 0.53, 0.86) in Caucasians. For rs2013162, the pooled MAF in 4 Caucasian-studies was 0.42 (95%CI: 0.32, 0.51). The pooled OR1 (AA vs CC) and OR2 (CA vs CC) were 0.87(95%CI: 0.71, 1.07) and 0.93(95%CI: 0.81, 1.08), respectively. Among 4 Caucasian studies for rs642961, the MAF was 0.20 (95% CI: 0.18, 0.23), and the pooled OR1 (AA Vs GG) and OR2 (GA Vs GG) were1.938 (95% CI: 1.443, 2.604) and 1.568 (95% CI:1.353, 1.819), respectively. Conclusion: This meta-analysis suggested association between IRF6 and NSCLP. Robust estimate suggested protective effect of rs2235371 in Asians and Caucasians and indicated risk effect of rs642961 in Caucasians.  

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