Year: 2011
Abstract: PS1/2
Category: Treatment Failure and Salvage Therapy

HIV over 50: Comparison between Newly and Long-infected Individuals
V. Soriano1, J. Cox2, J.J. Eron3, P. Kumar4, C. Katlama5, A. Lazzarin6, I. Poizot-Martin7, G.J. Richmond8, M. Ait-Khaled9, T. Fujiwara10, J. Huang11, S. Min12, C. Vavro12, J.M. Yeo9
1Hospital Carlos III, Madrid, Spain, 2Montreal General Hospital, Montreal, Canada, 3Center for AIDS Research Clinical Care, UNC School of Medicine, Chapel Hill, United States, 4George Town University, Washington, United States, 5Hôpital de La Pitié-Salpêtrière, Paris, France, 6San Raffaele Scientific Institute, Milan, Italy, 7Hôpital Sainte Marguerite, Marseille, France, 8Fort Lauderdale, Fort Lauderdale, United States, 9GlaxoSmithKline, Stockley Park, London, United Kingdom, 10Shionogi & Co., Ltd, Osaka, Japan, 11GlaxoSmithKline, Toronto, Canada, 12GlaxoSmithKline, Research Triangle Park, United States
Objectives: As HIV treatment improves, people are living longer with their infection. Additionally, older people constitute a substantial portion of new HIV diagnoses. As such, a better understanding of the interaction between age and length of infection in people living with HIV (PLHIV) is essential. br /
Methods: We use observational data on PLHIV from Clinique medicale l’Actuel, a sexual health clinic in Montreal, to assess the profiles of older patients. Treatment-experienced PLHIV >50 years were split into two groups created on a theoretical basis: those infected with HIV for <10 years (newly infected) and those infected for >20 years (long-infected). We compared sociodemographics and health variables between groups using t-test and chi-square for continuous and categorical variables, respectively. br /
Results: At l’Actuel, 14% of patients diagnosed with HIV in 2016 were >50 years and 52% of all PLHIV are >50 years. Among 1494 patients >50 years, 243 (16%) have been infected for <10 years and 764 (51 %), for >20 years. Long-infected patients are more prone to have smoked in their life and to have been infected with HBV and/or HCV compared with newly infected patients. Mean scores for liver function are higher, but within normal limits, for long-infected as compared with newly-infected patients; likely attributable to greater burden of HCV/HBV infection in this group. Long-infected patients tend to present lower viral loads (VL) at treatment initiation and a higher CD4 count at diagnosis, but similar most recent VL and CD4 /
Conclusion: Despite a potential exposure to more toxic ARVs, long-infected patients show similar health results to newly-infected patients’, suggesting they had access to appropriate care. However, these results do not take into account the impact of the duration of HIV infection on the quality of life and mental health. Further research into the psychosocial impacts of HIV is needed. NT NT NT
Presenter: Vincente Soriano, Hospital Carlos III, Madrid, Spain