Abstract
 
Environmental Factors in Alzheimer's and Parkinson's Disease: What about Dietary Fats? Print
 
F. Calon
Pharmacy, Université Laval, Quebec City, QC, Canada
 
There is a general consensus that environmental factors play a role in the pathogenesis of both Alzheimer's and Parkinson's diseases. Environmental factors are generally modifiable whereas genetic factors are not. Over the last 10 years, our group has generated data indicating that brain lipids concentrations highly depend on dietary intake. Our preclinical results show that treatments with omega-3 polyunsaturated acids improve cognition, provide neuroprotection, reduce neuroinflammation and influence neuronal function, while high-fat diets exert deleterious effects. Our experiments have been conducted mainly in well-recognized animal models of Alzheimer's and Parkinson's diseases, and more recently in a model of ischemic stroke. Beneficial effects were also documented with dietary polyphenols, such as resveratrol. In the light of these studies, it can be speculated that adjustment of lipids or polyphenols consumption from the diet may prove to be a cost-effective preventive strategy to optimize brain function and prevent Alzheimer's and Parkinson's diseases.
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Assigned speakers:
Dr. Frederic Calon, Université Laval , Quebec , Canada

Assigned in sessions:
06.03.2013, 11:00-13:00, Clinical, SYM05, SYMPOSIUM 05 NUTRITION BASED TREATMENTS SUPPORTED BY AN UNRESTRICTED EDUCATIONAL GRANT BY NUTRICIA, Hall B