|Targeting Synaptic Dysfunction in Alzheimer's Disease by Administrating the Specific Nutrient Combination Fortasyn Connect|| |
|1Nutricia Advanced Medical Nutrition, Danone Research, Centre for Specialised Nutrition, Wageningen, 2Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, The Netherlands|
|Objectives: Synaptic loss has been recognized to be the strongest structural correlate with memory impairment in Alzheimer's disease (AD) and is apparent early in the disease process. Synapses and neurites consist of neuronal membranes largely composed of phosphatides. Phosphatide synthesis depends on the presence of the dietary precursors DHA, UMP and choline. Additionally, B-vitamins, phospholipids and antioxidants are cofactors in the synthesis pathway of neuronal membranes. The role of nutrition in AD has been underscored by several studies demonstrating increased AD risk when adhering specific dietary patterns, and by the lowered plasma nutrient status in AD.|
Methods: A prerequisite for synapse formation is an adequate production of membrane phospholipids. Supplementation with combinations of the dietary precursors DHA, UMP and choline with the cofactors B-vitamins, antioxidants and phospholipids showed to increase synaptic formation and function parameters such as: neurite outgrowth, mRNA expression of synaptic proteins, synaptic protein levels, learning and memory.
Results: Based on these insights the specific nutrient combination Fortasyn® Connect (UMP, DHA, EPA, choline, phospholipids, folate, vitamins B6, B12, C, E, selenium) and contained within the Medical Food Souvenaid® was designed to support synapse formation and function in AD patients.
Conclusions: Supplementation of Fortasyn Connect in AD-animal-models improved learning, memory, cholinergic transmission and brain connectivity parameters. Furthermore, the potential of Fortasyn Connect in other neurological conditions is explored. In the 6-hydroxydopamine-lesion model of Parkinson's disease Fortasyn Connect nutrients partially restored dopaminergic neurotransmission. The main and latest findings will be presented.
Souvenaid and Fortasyn are registered trademarks of N.V. Nutricia.
Dr. Patrick Kamphuis, Nutricia Advanced Medical Nutrition, Danone Research, Centre for Specialised Nutrition , Wageningen , The Netherlands
Assigned in sessions:
06.03.2013, 11:00-13:00, Clinical, SYM05, SYMPOSIUM 05
NUTRITION BASED TREATMENTS
SUPPORTED BY AN UNRESTRICTED EDUCATIONAL GRANT BY NUTRICIA, Hall B