Abstract
 
Different Nutritional Status in Patients with Mild Alzheimer's Disease Compared to Healthy Controls Print
 
M.G.M. Olde Rikkert1, J.W. Sijben2, P. Scheltens3, A.M.J. van Hees2, M. Groenendijk2, P.J.G.H. Kamphuis2
1Alzheimer Centre Nijmegen, Radboud University Medical Centre Nijmegen, Nijmegen, 2Nutricia Advanced Medical Nutrition, Danone Research, Centre for Specialised Nutrition, Wageningen, 3Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
 
Objectives: Epidemiological studies suggest that low intake of n-3 fatty acids, B-vitamins and antioxidants increase risk of Alzheimer's disease (AD). Other studies suggest that AD patients have lower plasma levels of these nutrients compared to age-matched controls, either due to reduced daily consumption, their increased use, different metabolism or a combination of these factors. In this study, nutritional status in AD was further explored by comparing baseline clinical nutritional characteristics and plasma nutrient concentrations in mild AD patients with healthy controls.
Methods: Nutritional status was assessed in a subgroup of Dutch drug-naïve patients with mild AD (MMSE≥20) from the Souvenir II RCT and Dutch healthy control subjects. Between-group differences in parameters were analysed using ANCOVA, including pre-specified covariates age and nutritional supplement use.
Results: 79 AD patients and 93 healthy controls were included in this investigation (overall age 72±8y, 48% male). The proportion of DHA (p=0.002) and total long-chain n-3 PUFA (p=0.009) in erythrocyte membranes, plasma selenium(p< 0.001, subgroup of subjects not using nutritional supplements) and the MNA screening score (p=0.003) were lower in AD patients versus controls, with similar trends for plasma uridine (p=0.074) and vitamin D (p=0.094). No statistically significant differences were observed for plasma fatty acids, choline, homocysteine, B-vitamins, vitamin A, vitamin E and BMI.
Conclusions: The nutritional status in mild AD patients is different from healthy controls. To our knowledge, this is the first time that a suggestion for lower plasma uridine levels in mild AD versus healthy controls has been observed, which warrants further investigation.


Assigned speakers:
Prof. Marcel Olde Rikkert, Radboud University Nijmegen Medical Centre , Nijmegen , The Netherlands

Assigned in sessions:
06.03.2013, 11:00-13:00, Clinical, SYM05, SYMPOSIUM 05 NUTRITION BASED TREATMENTS SUPPORTED BY AN UNRESTRICTED EDUCATIONAL GRANT BY NUTRICIA, Hall B